Assay Detail
Functional
CHEMBL3270915
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human mu opioid receptor transfected in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.95 | 7.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262547 | — | — | 1 | 7.65 |
| CHEMBL3262548 | — | — | 1 | 7.63 |
| CHEMBL3262546 | — | — | 1 | 7.54 |
| CHEMBL38874 | DAMGO | — | 1 | 7.49 |
| CHEMBL3262549 | — | — | 1 | 7.40 |
| CHEMBL3262544 | — | — | 1 | 7.25 |
| CHEMBL3262545 | — | — | 1 | 7.09 |
| CHEMBL3262542 | — | — | 1 | 6.39 |
| CHEMBL3262551 | — | — | 1 | 6.17 |
| CHEMBL3262543 | — | — | 1 | 6.13 |
| CHEMBL3262552 | — | — | 1 | 5.68 |
| CHEMBL3262550 | — | — | 1 | - |
| CHEMBL3262553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262547 | — | EC50 | = | 22.3 | nM | 7.65 |
| CHEMBL3262548 | — | EC50 | = | 23.4 | nM | 7.63 |
| CHEMBL3262546 | — | EC50 | = | 28.7 | nM | 7.54 |
| CHEMBL38874 | DAMGO | EC50 | = | 32.6 | nM | 7.49 |
| CHEMBL3262549 | — | EC50 | = | 39.5 | nM | 7.40 |
| CHEMBL3262544 | — | EC50 | = | 56.9 | nM | 7.25 |
| CHEMBL3262545 | — | EC50 | = | 81.4 | nM | 7.09 |
| CHEMBL3262542 | — | EC50 | = | 409.0 | nM | 6.39 |
| CHEMBL3262551 | — | EC50 | = | 673.0 | nM | 6.17 |
| CHEMBL3262543 | — | EC50 | = | 745.0 | nM | 6.13 |
| CHEMBL3262552 | — | EC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL3262550 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3262553 | — | EC50 | > | 10000.0 | nM | - |