Assay Detail
Functional
CHEMBL3271334
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Antiproliferative activity against human A2780 cells assessed as cell viability after 72 hrs by SRB assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.78 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3260362 | — | — | 1 | 8.89 |
| CHEMBL3260364 | — | — | 1 | 8.66 |
| CHEMBL3260361 | — | — | 1 | 8.62 |
| CHEMBL3260363 | — | — | 1 | 8.49 |
| CHEMBL3260358 | — | — | 1 | 8.37 |
| CHEMBL3260360 | — | — | 1 | 8.35 |
| CHEMBL3260359 | — | — | 1 | 8.32 |
| CHEMBL2420666 | — | — | 1 | 8.22 |
| CHEMBL3260357 | — | — | 1 | 8.22 |
| CHEMBL3260366 | — | — | 1 | 8.16 |
| CHEMBL3260367 | — | — | 1 | 7.92 |
| CHEMBL2420667 | — | — | 1 | 7.89 |
| CHEMBL3260365 | — | — | 1 | 7.51 |
| CHEMBL3260353 | — | — | 1 | 7.46 |
| CHEMBL3260351 | — | — | 1 | 7.41 |
| CHEMBL3260354 | — | — | 1 | 7.35 |
| CHEMBL3260356 | — | — | 1 | 7.35 |
| CHEMBL3260347 | — | — | 1 | 7.18 |
| CHEMBL3260346 | — | — | 1 | 7.06 |
| CHEMBL3260352 | — | — | 1 | 6.68 |
| CHEMBL3260355 | — | — | 1 | 6.55 |
| CHEMBL3259825 | — | — | 1 | 6.48 |
| CHEMBL3260343 | — | — | 1 | - |
| CHEMBL3260344 | — | — | 1 | - |
| CHEMBL3260345 | — | — | 1 | - |
| CHEMBL3260348 | — | — | 1 | - |
| CHEMBL3260349 | — | — | 1 | - |
| CHEMBL3260350 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3260362 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3260364 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3260361 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3260363 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3260358 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3260360 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3260359 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2420666 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3260357 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3260366 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL3260367 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2420667 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3260365 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3260353 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3260351 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3260354 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3260356 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3260347 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3260346 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3260352 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3260355 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3259825 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3260343 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3260344 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3260345 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3260348 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3260349 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3260350 | — | IC50 | > | 2000.0 | nM | - |