Assay Detail
Binding
CHEMBL3281100
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Inhibition of amidase activity of bovine thrombin using BPVANA as substrate after 15 to 40 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel bis(benzamidino) compounds with an aromatic central link. Inhibitors of thrombin, pancreatic kallikrein, trypsin, and complement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.64 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3277923 | — | — | 1 | 6.96 |
| CHEMBL3277922 | — | — | 1 | 6.80 |
| CHEMBL3277935 | — | — | 1 | 6.57 |
| CHEMBL3277934 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3277923 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3277922 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3277935 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL3277934 | — | Ki | = | 570.0 | nM | 6.24 |