Assay Detail
Binding
CHEMBL3281634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 2 x 10'-8 M of [1,2,3-3H]-triamcinolone acetonide from glucocorticoid receptor in soluble fraction of mouse L929 cells after 20 hrs
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological action of two glucocorticoid alkylating agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.25 | 8.12 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3273976 | — | — | 1 | 8.12 |
| CHEMBL3273977 | — | — | 1 | 6.37 |
| CHEMBL427 | MECHLORETHAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3273976 | — | Kd | = | 7.5 | nM | 8.12 |
| CHEMBL3273977 | — | Kd | = | 430.0 | nM | 6.37 |
| CHEMBL427 | MECHLORETHAMINE | Inhibition | - | % | - |