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Evidence Snapshot

Glucocorticoid receptor

CHEMBL3144 SINGLE PROTEIN Mus musculus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:41Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3144
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glucocorticoid receptor as ChEMBL target CHEMBL3144, mapped to UniProt P06537. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glucocorticoid receptor
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL3144
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P06537
Glucocorticoid receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Glucocorticoid receptor matters

As of 2026-09-13

Glucocorticoid receptor is reviewed as Glucocorticoid receptor (UniProt P06537); the current evidence base includes 4 approved drugs, 74 compounds, and 31 assays, with lead potency reaching pChEMBL 8.7.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 4 approved drugs, 74 compounds, and 31 assays for this target. The dominant activity type is EC50. CHEMBL1276308 is the current potency anchor at pChEMBL 8.7.

Use CHEMBL1276308 as the tractability anchor when discussing potency (pChEMBL 8.7).

Activity source · ChEMBL 36 via Core Engine
4 approved pChEMBL 8.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Glucocorticoid receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P06537, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

74
Total Compounds
31
Total Assays
4
Approved Drugs
IC50: 3.0, EC50: 31.0, KD: 4.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL1276308
 8.7 IC50 Approved
No preferred name
CHEMBL372684
 8.5 EC50 —
No preferred name
CHEMBL131
 8.5 EC50 Approved
No preferred name
CHEMBL82546
 8.4 EC50 —
No preferred name
CHEMBL364015
 8.3 EC50 —

Approved Drugs

Structure Compound First Approval
MIFEPRISTONE
CHEMBL1276308
 2000
PREDNISOLONE
CHEMBL131
 1955
HYDROCORTISONE HEMISUCCINATE ANHYDROUS
CHEMBL977
 1955
HYDROCORTISONE
CHEMBL389621
 1952
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:41Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3144