Compound Detail
CHEMBL977
HYDROCORTISONE HEMISUCCINATE ANHYDROUS 💊 Approved Drug
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💊 Approved Drug
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)COC(=O)CCC(=O)O
Basic Information
| ChEMBL ID | CHEMBL977 |
| Name | HYDROCORTISONE HEMISUCCINATE ANHYDROUS |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | VWQWXZAWFPZJDA-CGVGKPPMSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL389621 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
3
Known Names
Molecular Properties
462.5
MW (Da)
2.20
ALogP
7
HBA
3
HBD
138.2
PSA (Ų)
0.51
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1955 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Activity Summary
Kd 1 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL3144 | Kd | 6.72 | 6.72 | 190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Kd | = | 190.0 | nM | 6.72 | Displacement of 1 x 10'-8 M of [1,2,3-3H]-triamcinolone acetonide from glucocort... | 926113 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26636180 | 10.1021/acs.jnatprod.5b00833 | Unchecked | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 2 |
| - | 10.6019/CHEMBL4513141 | Klebsiella pneumoniae | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Acetylcholinesterase | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Estrogen receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | D(1A) dopamine receptor | 1 |
| - | 10.6019/CHEMBL4513141 | Staphylococcus aureus | 1 |
| - | 10.6019/CHEMBL4513141 | Acinetobacter baumannii | 1 |
| - | 10.6019/CHEMBL4513141 | Pseudomonas aeruginosa | 1 |
| 8642563 | 10.1021/jm950874+ | Human immunodeficiency virus type 1 protease | 1 |
| - | 10.6019/CHEMBL4513141 | Cryptococcus neoformans | 1 |
| - | 10.6019/CHEMBL4513141 | Candida albicans | 1 |
| 926113 | 10.1021/jm00219a005 | Glucocorticoid receptor | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 17616582 | 10.1073/pnas.0702671104 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine