Assay Detail
Binding
CHEMBL3281632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 1 x 10'-8 M of [1,2,3-3H]-triamcinolone acetonide from glucocorticoid receptor in soluble fraction of mouse L929 cells after 20 hrs
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological action of two glucocorticoid alkylating agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| Kd | 2 | 7.05 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 1 | 7.37 |
| CHEMBL977 | HYDROCORTISONE HEMISUCCINATE ANHYDROUS | 4.0 | 1 | 6.72 |
| CHEMBL3273978 | — | — | 1 | - |
| CHEMBL1641 | HYDROCORTISONE PHOSPHORIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389621 | HYDROCORTISONE | Kd | = | 43.0 | nM | 7.37 |
| CHEMBL977 | HYDROCORTISONE HEMISUCCINATE ANHYDROUS | Kd | = | 190.0 | nM | 6.72 |
| CHEMBL3273978 | — | Inhibition | - | % | - | |
| CHEMBL1641 | HYDROCORTISONE PHOSPHORIC ACID | Inhibition | - | % | - |