Assay Detail
Binding
CHEMBL3293050
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Inhibition of human CYP11B1 expressed in hamster V79MZh cells using deoxycorticosterone as substrate
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.19 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 8.54 |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 8.20 |
| CHEMBL3287192 | — | — | 1 | 7.47 |
| CHEMBL3287178 | — | — | 1 | 7.28 |
| CHEMBL3287193 | — | — | 1 | 7.21 |
| CHEMBL3287187 | — | — | 1 | 6.80 |
| CHEMBL3287189 | — | — | 1 | 6.52 |
| CHEMBL3287188 | — | — | 1 | 6.44 |
| CHEMBL3287194 | — | — | 1 | 6.36 |
| CHEMBL3287179 | — | — | 1 | 6.29 |
| CHEMBL1765205 | — | — | 1 | 6.15 |
| CHEMBL3287191 | — | — | 1 | 6.13 |
| CHEMBL3287185 | — | — | 1 | 6.09 |
| CHEMBL3287190 | — | — | 1 | 5.86 |
| CHEMBL3287171 | — | — | 1 | 5.85 |
| CHEMBL3287177 | — | — | 1 | 5.82 |
| CHEMBL3286405 | — | — | 1 | 5.64 |
| CHEMBL3287169 | — | — | 1 | 5.54 |
| CHEMBL3287184 | — | — | 1 | 5.50 |
| CHEMBL3287180 | — | — | 1 | 5.43 |
| CHEMBL3287186 | — | — | 1 | 5.42 |
| CHEMBL3287172 | — | — | 1 | 5.39 |
| CHEMBL3287170 | — | — | 1 | 5.32 |
| CHEMBL3287181 | — | — | 1 | 5.21 |
| CHEMBL3287182 | — | — | 1 | 5.18 |
| CHEMBL3287183 | — | — | 1 | 5.17 |
| CHEMBL3287176 | — | — | 1 | - |
| CHEMBL3287175 | — | — | 1 | - |
| CHEMBL3287174 | — | — | 1 | - |
| CHEMBL3287173 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3287192 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3287178 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3287193 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3287187 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3287189 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL3287188 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL3287194 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL3287179 | — | IC50 | = | 516.0 | nM | 6.29 |
| CHEMBL1765205 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL3287191 | — | IC50 | = | 736.0 | nM | 6.13 |
| CHEMBL3287185 | — | IC50 | = | 803.0 | nM | 6.09 |
| CHEMBL3287190 | — | IC50 | = | 1379.0 | nM | 5.86 |
| CHEMBL3287171 | — | IC50 | = | 1423.0 | nM | 5.85 |
| CHEMBL3287177 | — | IC50 | = | 1523.0 | nM | 5.82 |
| CHEMBL3286405 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3287169 | — | IC50 | = | 2848.0 | nM | 5.54 |
| CHEMBL3287184 | — | IC50 | = | 3125.0 | nM | 5.50 |
| CHEMBL3287180 | — | IC50 | = | 3723.0 | nM | 5.43 |
| CHEMBL3287186 | — | IC50 | = | 3756.0 | nM | 5.42 |
| CHEMBL3287172 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3287170 | — | IC50 | = | 4737.0 | nM | 5.32 |
| CHEMBL3287181 | — | IC50 | = | 6093.0 | nM | 5.21 |
| CHEMBL3287182 | — | IC50 | = | 6642.0 | nM | 5.18 |
| CHEMBL3287183 | — | IC50 | = | 6812.0 | nM | 5.17 |
| CHEMBL3287176 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3287175 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3287174 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3287173 | — | IC50 | > | 5000.0 | nM | - |