Assay Detail
Binding
CHEMBL3294241
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Binding affinity to EP1 receptor (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL1811) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Prostanoid receptor EP2 as a therapeutic target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.82 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 7.75 |
| CHEMBL3286796 | — | — | 1 | 5.89 |
| CHEMBL271896 | BUTAPROST | 2.0 | 1 | - |
| CHEMBL1628262 | — | — | 1 | - |
| CHEMBL64246 | — | — | 1 | - |
| CHEMBL1722929 | — | — | 1 | - |
| CHEMBL563646 | EVATANEPAG | 2.0 | 1 | - |
| CHEMBL2107783 | TAPRENEPAG | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3286796 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL271896 | BUTAPROST | Ki | > | 10000.0 | nM | - |
| CHEMBL1628262 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL64246 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1722929 | — | Ki | - | — | - | |
| CHEMBL563646 | EVATANEPAG | Ki | > | 2800.0 | nM | - |
| CHEMBL2107783 | TAPRENEPAG | Ki | > | 3200.0 | nM | - |