Assay Detail
Binding
CHEMBL3296556
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-hydroxy[3H]tryptamine uptake at human SERT expressed in African green monkey COS7 cells incubated for 10 mins prior to radioligand addition measured after 5 mins by scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.25 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1508 | ESCITALOPRAM | 4.0 | 1 | 8.13 |
| CHEMBL3287656 | — | — | 1 | 7.47 |
| CHEMBL3287655 | — | — | 1 | 7.43 |
| CHEMBL196760 | — | — | 1 | 7.03 |
| CHEMBL3287653 | — | — | 1 | 6.85 |
| CHEMBL3287654 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1508 | ESCITALOPRAM | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL3287656 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL3287655 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL196760 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL3287653 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL3287654 | — | Ki | = | 250.0 | nM | 6.60 |