Assay Detail
Functional
CHEMBL3362298
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Cytotoxicity against human DU145 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.58 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3322519 | — | — | 1 | 8.00 |
| CHEMBL98745 | NARCICLASINE | — | 1 | 7.52 |
| CHEMBL1808972 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3322519 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL98745 | NARCICLASINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1808972 | — | IC50 | = | 60.0 | nM | 7.22 |