Assay Detail
ADMET
CHEMBL3362763
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Inhibition of CYP2D6 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.69 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3323095 | — | — | 1 | 6.10 |
| CHEMBL3323187 | — | — | 1 | 6.00 |
| CHEMBL3323181 | — | — | 1 | 4.96 |
| CHEMBL3323173 | — | — | 1 | - |
| CHEMBL3323174 | — | — | 1 | - |
| CHEMBL3323175 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3323095 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3323187 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3323181 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3323173 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL3323174 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL3323175 | — | IC50 | < | 1000.0 | nM | - |