Assay Detail
Binding
CHEMBL3363471
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Inhibition of p38alpha MAPK (unknown origin) by radiometric assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38α MAPK, CK1δ and JAK2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.02 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3120970 | — | — | 1 | 8.07 |
| CHEMBL278041 | SB-202190 | — | 1 | 8.05 |
| CHEMBL3314285 | — | — | 1 | 7.02 |
| CHEMBL3120986 | — | — | 1 | 7.02 |
| CHEMBL3314271 | — | — | 1 | 6.92 |
| CHEMBL3120995 | — | — | 1 | 6.78 |
| CHEMBL3120983 | — | — | 1 | 6.73 |
| CHEMBL3120960 | — | — | 1 | 6.68 |
| CHEMBL3314273 | — | — | 1 | 6.60 |
| CHEMBL3120985 | — | — | 1 | 6.46 |
| CHEMBL3120963 | — | — | 1 | 6.11 |
| CHEMBL3314270 | — | — | 1 | 5.99 |
| CHEMBL3314283 | — | — | 1 | 5.94 |
| CHEMBL3120969 | — | — | 1 | 5.61 |
| CHEMBL3314272 | — | — | 1 | 5.60 |
| CHEMBL3314284 | — | — | 1 | 5.60 |
| CHEMBL3313935 | — | — | 1 | 5.53 |
| CHEMBL3314281 | — | — | 1 | 5.30 |
| CHEMBL3314282 | — | — | 1 | 5.17 |
| CHEMBL3314276 | — | — | 1 | 5.03 |
| CHEMBL3314274 | — | — | 1 | 4.92 |
| CHEMBL3314277 | — | — | 1 | 4.73 |
| CHEMBL3314278 | — | — | 1 | 4.48 |
| CHEMBL3314286 | — | — | 1 | 4.09 |
| CHEMBL3314280 | — | — | 1 | - |
| CHEMBL3314279 | — | — | 1 | - |
| CHEMBL3314275 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3120970 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL278041 | SB-202190 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3314285 | — | IC50 | = | 95.5 | nM | 7.02 |
| CHEMBL3120986 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3314271 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3120995 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL3120983 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL3120960 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3314273 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3120985 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL3120963 | — | IC50 | = | 783.0 | nM | 6.11 |
| CHEMBL3314270 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3314283 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL3120969 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL3314272 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL3314284 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL3313935 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL3314281 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL3314282 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL3314276 | — | IC50 | = | 9390.0 | nM | 5.03 |
| CHEMBL3314274 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3314277 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL3314278 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL3314286 | — | IC50 | = | 82100.0 | nM | 4.09 |
| CHEMBL3314280 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3314279 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3314275 | — | IC50 | > | 100000.0 | nM | - |