Assay Detail
Binding
CHEMBL3363472
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Inhibition of CK1-delta (unknown origin) by radiometric assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38α MAPK, CK1δ and JAK2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.41 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3120983 | — | — | 1 | 7.05 |
| CHEMBL278041 | SB-202190 | — | 1 | 6.73 |
| CHEMBL3120960 | — | — | 1 | 6.70 |
| CHEMBL3120985 | — | — | 1 | 6.65 |
| CHEMBL3120963 | — | — | 1 | 6.62 |
| CHEMBL3314270 | — | — | 1 | 6.36 |
| CHEMBL3120986 | — | — | 1 | 6.36 |
| CHEMBL3120995 | — | — | 1 | 5.80 |
| CHEMBL3120969 | — | — | 1 | 5.51 |
| CHEMBL3314285 | — | — | 1 | 5.22 |
| CHEMBL3314280 | — | — | 1 | 4.97 |
| CHEMBL3314284 | — | — | 1 | 4.92 |
| CHEMBL3314283 | — | — | 1 | 4.92 |
| CHEMBL3314277 | — | — | 1 | 4.75 |
| CHEMBL3314281 | — | — | 1 | 4.71 |
| CHEMBL3314276 | — | — | 1 | 4.70 |
| CHEMBL3314282 | — | — | 1 | 4.67 |
| CHEMBL3314274 | — | — | 1 | 4.67 |
| CHEMBL3314278 | — | — | 1 | 4.61 |
| CHEMBL3313935 | — | — | 1 | 4.61 |
| CHEMBL3314279 | — | — | 1 | 4.35 |
| CHEMBL3314286 | — | — | 1 | 4.18 |
| CHEMBL3314275 | — | — | 1 | - |
| CHEMBL3314273 | — | — | 1 | - |
| CHEMBL3314272 | — | — | 1 | - |
| CHEMBL3314271 | — | — | 1 | - |
| CHEMBL3120970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3120983 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL278041 | SB-202190 | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL3120960 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL3120985 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL3120963 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3314270 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL3120986 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL3120995 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3120969 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3314285 | — | IC50 | = | 5960.0 | nM | 5.22 |
| CHEMBL3314280 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3314284 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL3314283 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3314277 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL3314281 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL3314276 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL3314282 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL3314274 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL3314278 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL3313935 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL3314279 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL3314286 | — | IC50 | = | 66300.0 | nM | 4.18 |
| CHEMBL3314275 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3314273 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3314272 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3314271 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3120970 | — | IC50 | > | 100000.0 | nM | - |