Assay Detail
Functional
CHEMBL3364239
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Antiviral activity against Influenza A virus (A/HK/7/1987(H3N2)) infected in MDCK cells assessed as reduction in host cell viability after 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Hong Kong/7/1987(H3N2)) |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Semisynthetic teicoplanin derivatives as new influenza virus binding inhibitors: synthesis and antiviral studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.90 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 7.34 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 6.30 |
| CHEMBL3310642 | — | — | 1 | 5.92 |
| CHEMBL3310643 | — | — | 1 | 5.66 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.14 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 5.05 |
| CHEMBL3310644 | — | — | 1 | - |
| CHEMBL3310645 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL660 | AMANTADINE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3310642 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3310643 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3310644 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3310645 | — | EC50 | > | 100000.0 | nM | - |