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Assay Detail

CHEMBL3364348

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Coxsackievirus B5 Faulkner (ATCC VR-185) infected in Vero 76 cells after 3 days by plaque reduction assays
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Coxsackievirus B5
Cell Type Vero 76
Confidence 1 — Organism
Curated By Autocuration

Target

Coxsackievirus B5 (CHEMBL613555)
Type ORGANISM
Organism Coxsackievirus B5

Publication

Synthesis and antiviral activity of new phenylimidazopyridines and N-benzylidenequinolinamines derived by molecular simplification of phenylimidazo[4,5-g]quinolines.
Loddo R, Briguglio I, Corona P, Piras S, Loriga M, Paglietti G, Carta A, Sanna G, Giliberti G, Ibba C, Farci P, La Colla P.
Eur J Med Chem (2014) 84 : 8 -16
PubMed 25014745 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 4.54 4.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3317511 1 4.80
CHEMBL3317500 1 4.75
CHEMBL3317505 1 4.70
CHEMBL98778 2'-ETHYNYL-D-CYTIDINE 1 4.57
CHEMBL3317509 1 4.54
CHEMBL3317508 1 4.34
CHEMBL3317504 1 4.07
CHEMBL237143 1 -
CHEMBL3317512 1 -
CHEMBL3317499 1 -
CHEMBL3317510 1 -
CHEMBL3317501 1 -
CHEMBL3317474 1 -
CHEMBL3317507 1 -
CHEMBL3317506 1 -
CHEMBL3317475 1 -
CHEMBL1940452 1 -
CHEMBL3317503 1 -
CHEMBL3317502 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3317511 EC50 = 16000.0 nM 4.80
CHEMBL3317500 EC50 = 18000.0 nM 4.75
CHEMBL3317505 EC50 = 20000.0 nM 4.70
CHEMBL98778 2'-ETHYNYL-D-CYTIDINE EC50 = 27000.0 nM 4.57
CHEMBL3317509 EC50 = 29000.0 nM 4.54
CHEMBL3317508 EC50 = 46000.0 nM 4.34
CHEMBL3317504 EC50 = 86000.0 nM 4.07
CHEMBL237143 EC50 > 100000.0 nM -
CHEMBL3317512 EC50 > 100000.0 nM -
CHEMBL3317499 EC50 > 73000.0 nM -
CHEMBL3317510 EC50 > 100000.0 nM -
CHEMBL3317501 EC50 > 100000.0 nM -
CHEMBL3317474 EC50 > 100000.0 nM -
CHEMBL3317507 EC50 > 100000.0 nM -
CHEMBL3317506 EC50 > 100000.0 nM -
CHEMBL3317475 EC50 > 50000.0 nM -
CHEMBL1940452 EC50 > 100000.0 nM -
CHEMBL3317503 EC50 > 40000.0 nM -
CHEMBL3317502 EC50 > 100000.0 nM -