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Compound Detail

CHEMBL3317510

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Nc1c(/N=C/c2ccc([N+](=O)[O-])cc2)cc2cccnc2c1Cl

Basic Information

ChEMBL ID CHEMBL3317510
Phase Preclinical
Structure Type MOL
InChI Key LXSVFYMFTXNQQO-AWQFTUOYSA-N
2
Targets
6
Activities
2
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

326.7
MW (Da)
4.13
ALogP
5
HBA
1
HBD
94.4
PSA (Ų)
0.34
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H11ClN4O2
MW 326.74
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness -1.36

Activity Summary

EC50 4 meas. best 5.77
IC50 2 meas. best 6.09

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 6.09 6.045 810.0 2
NON-PROTEIN TARGET
CHEMBL3879801
EC50 5.77 5.1125 1700.0 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25014745 10.1016/j.ejmech.2014.07.011 NON-PROTEIN TARGET 4
27161176 10.1016/j.ejmech.2016.03.080 Unchecked 4
25014745 10.1016/j.ejmech.2014.07.011 ADMET 3
25014745 10.1016/j.ejmech.2014.07.011 MT4 1
25014745 10.1016/j.ejmech.2014.07.011 Human immunodeficiency virus 1 1
25014745 10.1016/j.ejmech.2014.07.011 Yellow fever virus 1
25014745 10.1016/j.ejmech.2014.07.011 Coxsackievirus B5 1
25014745 10.1016/j.ejmech.2014.07.011 Human poliovirus 1 strain Sabin 1
25014745 10.1016/j.ejmech.2014.07.011 Vesicular stomatitis Indiana virus 1
25014745 10.1016/j.ejmech.2014.07.011 Human alphaherpesvirus 1 1
27161176 10.1016/j.ejmech.2016.03.080 NON-PROTEIN TARGET 1

Data from ChEMBL 36 via Core Engine