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Assay Detail

CHEMBL3364543

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(1A) dopamine receptor (CHEMBL2056)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structural manipulation on the catecholic fragment of dopamine D(1) receptor agonist 1-phenyl-N-methyl-benzazepines.
Zhang J, Huang J, Song Z, Guo L, Cai W, Wang Y, Zhen X, Zhang A.
Eur J Med Chem (2014) 85 : 16 -26
PubMed 25076379 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 6.40 6.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1193274 1 6.68
CHEMBL3325913 1 6.67
CHEMBL3325905 1 6.56
CHEMBL3325907 1 6.54
CHEMBL3325901 1 6.48
CHEMBL3325903 1 6.46
CHEMBL3325916 1 6.46
CHEMBL3325906 1 6.43
CHEMBL286080 SKF-38393 1 6.41
CHEMBL3325920 1 6.23
CHEMBL3325904 1 6.18
CHEMBL3325908 1 6.12
CHEMBL3325914 1 6.04
CHEMBL3325911 1 -
CHEMBL3325912 1 -
CHEMBL3325909 1 -
CHEMBL3325915 1 -
CHEMBL3325917 1 -
CHEMBL3325918 1 -
CHEMBL3356088 1 -
CHEMBL3325921 1 -
CHEMBL3325922 1 -
CHEMBL3325923 1 -
CHEMBL3325924 1 -
CHEMBL3325925 1 -
CHEMBL3325926 1 -
CHEMBL3325902 1 -
CHEMBL3325919 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1193274 Ki = 207.0 nM 6.68
CHEMBL3325913 Ki = 216.0 nM 6.67
CHEMBL3325905 Ki = 277.0 nM 6.56
CHEMBL3325907 Ki = 292.0 nM 6.54
CHEMBL3325901 Ki = 334.0 nM 6.48
CHEMBL3325903 Ki = 351.0 nM 6.46
CHEMBL3325916 Ki = 349.0 nM 6.46
CHEMBL3325906 Ki = 370.0 nM 6.43
CHEMBL286080 SKF-38393 Ki = 393.0 nM 6.41
CHEMBL3325920 Ki = 583.0 nM 6.23
CHEMBL3325904 Ki = 665.0 nM 6.18
CHEMBL3325908 Ki = 756.0 nM 6.12
CHEMBL3325914 Ki = 912.0 nM 6.04
CHEMBL3325911 Ki > 1000.0 nM -
CHEMBL3325912 Ki > 1000.0 nM -
CHEMBL3325909 Ki > 1000.0 nM -
CHEMBL3325915 Ki > 1000.0 nM -
CHEMBL3325917 Ki > 1000.0 nM -
CHEMBL3325918 Ki > 1000.0 nM -
CHEMBL3356088 Ki > 1000.0 nM -
CHEMBL3325921 Ki > 1000.0 nM -
CHEMBL3325922 Ki > 1000.0 nM -
CHEMBL3325923 Ki > 1000.0 nM -
CHEMBL3325924 Ki > 1000.0 nM -
CHEMBL3325925 Ki > 1000.0 nM -
CHEMBL3325926 Ki > 1000.0 nM -
CHEMBL3325902 Ki > 1000.0 nM -
CHEMBL3325919 Ki > 1000.0 nM -