Assay Detail
Functional
CHEMBL3365080
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Antitrypanosomal activity against Trypanosoma cruzi Tulahuen trypomastigotes expressing green florescent protein infected in cardiomyocytes assessed as inhibition of parasite growth after 72 hrs by fluorescence microscopy
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 8.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385091 | — | — | 1 | 9.00 |
| CHEMBL2386135 | — | — | 1 | 8.92 |
| CHEMBL3318325 | — | — | 1 | 8.92 |
| CHEMBL3318326 | — | — | 1 | 8.89 |
| CHEMBL3318324 | — | — | 1 | 8.82 |
| CHEMBL3318323 | — | — | 1 | 8.60 |
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 8.30 |
| CHEMBL3318310 | — | — | 1 | 8.26 |
| CHEMBL2386134 | — | — | 1 | 7.82 |
| CHEMBL3318309 | — | — | 1 | 7.70 |
| CHEMBL2386136 | — | — | 1 | 7.66 |
| CHEMBL3318311 | — | — | 1 | - |
| CHEMBL3318322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385091 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2386135 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3318325 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3318326 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3318324 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3318323 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1397 | POSACONAZOLE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3318310 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL2386134 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3318309 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2386136 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3318311 | — | EC50 | - | — | - | |
| CHEMBL3318322 | — | EC50 | - | — | - |