Assay Detail
Functional
CHEMBL3365600
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human WI38 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WI-38 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluations of tumor-targeting dual-warhead conjugates for a taxoid-camptothecin combination chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.40 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298846 | — | — | 1 | 8.23 |
| CHEMBL3298847 | — | — | 1 | 6.13 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.11 |
| CHEMBL3298848 | — | — | 1 | 6.06 |
| CHEMBL3298849 | — | — | 1 | 6.03 |
| CHEMBL3298850 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298846 | — | IC50 | = | 5.89 | nM | 8.23 |
| CHEMBL3298847 | — | IC50 | = | 742.0 | nM | 6.13 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 786.0 | nM | 6.11 |
| CHEMBL3298848 | — | IC50 | = | 868.0 | nM | 6.06 |
| CHEMBL3298849 | — | IC50 | = | 941.0 | nM | 6.03 |
| CHEMBL3298850 | — | IC50 | = | 1440.0 | nM | 5.84 |