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Compound Detail

CHEMBL3298847

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CC[C@@]1(OC(=O)Cc2ccccc2SSC(C)CCC(=O)NCCOCCOCCOCCn2cc(CNc3nc(NCCNC(=O)CCC(C)SSc4ccccc4CC(=O)O[C@@H](C(=O)O[C@H]4C[C@@]5(O)[C@@H](OC(=O)c6ccccc6)[C@@H]6[C@]7(OC(C)=O)CCO[C@@H]7C[C@H](O)[C@@]6(C)C(=O)[C@H](OC(=O)C6CC6)C(=C4C)C5(C)C)[C@H](C=C(C)C)NC(=O)OC(C)(C)C)nc(NCCOCCOCCOCCNC(=O)CCCC[C@@H]4SC[C@@H]5NC(=O)N[C@@H]54)n3)nn2)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1

Basic Information

ChEMBL ID CHEMBL3298847
Phase Preclinical
Structure Type MOL
InChI Key AMZFRWYLXVDAPU-HUMVEERVSA-N
4
Targets
10
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

2572.1
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C126H163N17O31S5
MW 2572.11

Activity Summary

IC50 10 meas. best 8.49

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
MCF7
CHEMBL387
IC50 8.49 8.105 3.2 2
NON-PROTEIN TARGET
CHEMBL3879801
IC50 8.24 7.0375 5.7 4
L1210
CHEMBL386
IC50 8.13 7.77 7.4 2
MX1
CHEMBL613704
IC50 8.01 7.65 9.8 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24901491 10.1021/jm500631u NON-PROTEIN TARGET 4
24901491 10.1021/jm500631u MCF7 3
24901491 10.1021/jm500631u MX1 2
24901491 10.1021/jm500631u L1210 2
24901491 10.1021/jm500631u ADMET 1

Data from ChEMBL 36 via Core Engine