Assay Detail
Binding
CHEMBL3366443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP11B1 expressed in V79 MZ cells pretreated with compound for 1 hr followed by addition of 500 nM 11-deoxycorticosterone for 3 hrs by HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZ |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.58 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL681 | ETOMIDATE | 4.0 | 1 | 9.30 |
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 7.34 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 6.92 |
| CHEMBL31215 | S-FADROZOLE | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL681 | ETOMIDATE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL934 | METYRAPONE | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL31215 | S-FADROZOLE | IC50 | = | 171.0 | nM | 6.77 |