Assay Detail
Functional
CHEMBL3366684
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Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.04 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3323240 | — | — | 1 | 5.52 |
| CHEMBL3323243 | — | — | 1 | 5.29 |
| CHEMBL3323242 | — | — | 1 | 5.27 |
| CHEMBL3323241 | — | — | 1 | 5.23 |
| CHEMBL3323246 | — | — | 1 | 4.95 |
| CHEMBL3323245 | — | — | 1 | 4.88 |
| CHEMBL3323247 | — | — | 1 | 4.70 |
| CHEMBL3323244 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3323240 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3323243 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3323242 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3323241 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3323246 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL3323245 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL3323247 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3323244 | — | IC50 | = | 33600.0 | nM | 4.47 |