Assay Detail
Binding
CHEMBL3366727
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Inhibition of Wistar rat intestinal isomaltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.47 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3311519 | — | — | 1 | 6.66 |
| CHEMBL3311515 | — | — | 1 | 6.20 |
| CHEMBL3311516 | — | — | 1 | 5.75 |
| CHEMBL3311518 | — | — | 1 | 5.52 |
| CHEMBL1641739 | — | — | 1 | 5.33 |
| CHEMBL476960 | VOGLIBOSE | 4.0 | 1 | 5.28 |
| CHEMBL3311517 | — | — | 1 | 5.22 |
| CHEMBL2177690 | — | — | 1 | 4.85 |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3311519 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3311515 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3311516 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3311518 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1641739 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL476960 | VOGLIBOSE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3311517 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2177690 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1561 | MIGLITOL | IC50 | = | 39000.0 | nM | 4.41 |