Assay Detail
Functional
CHEMBL3366950
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Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse C2C12 cells after 72 hrs by DAPI staining method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | C2C12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.76 | 10.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3259946 | — | — | 1 | 10.77 |
| CHEMBL3259944 | — | — | 1 | 9.92 |
| CHEMBL3259945 | — | — | 1 | 8.89 |
| CHEMBL3337539 | — | — | 1 | 8.17 |
| CHEMBL3337540 | — | — | 1 | 7.77 |
| CHEMBL3337534 | — | — | 1 | 7.68 |
| CHEMBL3337541 | — | — | 1 | 7.54 |
| CHEMBL3337532 | — | — | 1 | 7.41 |
| CHEMBL3337537 | — | — | 1 | 7.23 |
| CHEMBL3337536 | — | — | 1 | 7.11 |
| CHEMBL3337535 | — | — | 1 | 6.77 |
| CHEMBL3337538 | — | — | 1 | 6.64 |
| CHEMBL3337533 | — | — | 1 | 6.55 |
| CHEMBL507264 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3259946 | — | EC50 | = | 0.017 | nM | 10.77 |
| CHEMBL3259944 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL3259945 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3337539 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL3337540 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3337534 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3337541 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3337532 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3337537 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3337536 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3337535 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3337538 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3337533 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL507264 | — | EC50 | = | 650.0 | nM | 6.19 |