Assay Detail
ADMET
CHEMBL3367086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A4 in human liver microsome
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.58 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3321845 | — | — | 1 | 6.60 |
| CHEMBL3321846 | — | — | 1 | 6.58 |
| CHEMBL3321850 | — | — | 1 | 6.57 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3321845 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3321846 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3321850 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | < | 62.0 | nM | - |