Assay Detail
Functional
CHEMBL3367334
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Inhibition of LPS-induced TNFalpha production in human THP1 cells after 24 hrs
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrano-isochromanones as IL-6 inhibitors: synthesis, in vitro and in vivo antiarthritic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.32 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL632 | BETAMETHASONE | 4.0 | 1 | 7.89 |
| CHEMBL273019 | BERGENIN | -1.0 | 1 | 4.90 |
| CHEMBL3326040 | — | — | 1 | 4.87 |
| CHEMBL3326044 | — | — | 1 | 4.87 |
| CHEMBL3326041 | — | — | 1 | 4.80 |
| CHEMBL3326047 | — | — | 1 | 4.59 |
| CHEMBL3326054 | — | — | 1 | - |
| CHEMBL3326053 | — | — | 1 | - |
| CHEMBL3326052 | — | — | 1 | - |
| CHEMBL3326051 | — | — | 1 | - |
| CHEMBL3326050 | — | — | 1 | - |
| CHEMBL3326049 | — | — | 1 | - |
| CHEMBL3326048 | — | — | 1 | - |
| CHEMBL3326046 | — | — | 1 | - |
| CHEMBL3326045 | — | — | 1 | - |
| CHEMBL3326042 | — | — | 1 | - |
| CHEMBL3326043 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL632 | BETAMETHASONE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL273019 | BERGENIN | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3326040 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL3326044 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL3326041 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3326047 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL3326054 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3326053 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3326052 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3326051 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3326050 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3326049 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3326048 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3326046 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3326045 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3326042 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3326043 | — | IC50 | > | 30000.0 | nM | - |