Assay Detail
ADMET
CHEMBL3367338
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Cytotoxicity against human THP1 cells after 48 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrano-isochromanones as IL-6 inhibitors: synthesis, in vitro and in vivo antiarthritic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.12 | 4.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3326045 | — | — | 1 | 4.17 |
| CHEMBL3326044 | — | — | 1 | 4.11 |
| CHEMBL273019 | BERGENIN | -1.0 | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3326045 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL3326044 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL273019 | BERGENIN | IC50 | = | 84000.0 | nM | 4.08 |