Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3367443

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine xanthine oxidase assessed as inhibition of uric acid formation after 30 mins by spectrophotometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Xanthine dehydrogenase/oxidase (CHEMBL3649)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors.
Guan Q, Cheng Z, Ma X, Wang L, Feng D, Cui Y, Bao K, Wu L, Zhang W.
Eur J Med Chem (2014) 85 : 508 -516
PubMed 25113879 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.62 8.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3331617 1 8.26
CHEMBL3331615 1 8.04
CHEMBL3331623 1 7.98
CHEMBL3331614 1 7.88
CHEMBL3331622 1 7.88
CHEMBL3331621 1 7.80
CHEMBL3331611 1 7.79
CHEMBL3331620 1 7.79
CHEMBL1164729 FEBUXOSTAT 4.0 1 7.73
CHEMBL3331613 1 7.61
CHEMBL3331616 1 7.54
CHEMBL3331619 1 7.51
CHEMBL3331610 1 7.47
CHEMBL3331618 1 7.45
CHEMBL3331612 1 7.39
CHEMBL3331624 1 7.34
CHEMBL3331609 1 7.31
CHEMBL3331625 1 7.27
CHEMBL3331607 1 7.18
CHEMBL3331608 1 7.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3331617 IC50 = 5.5 nM 8.26
CHEMBL3331615 IC50 = 9.1 nM 8.04
CHEMBL3331623 IC50 = 10.4 nM 7.98
CHEMBL3331614 IC50 = 13.2 nM 7.88
CHEMBL3331622 IC50 = 13.3 nM 7.88
CHEMBL3331621 IC50 = 15.7 nM 7.80
CHEMBL3331611 IC50 = 16.1 nM 7.79
CHEMBL3331620 IC50 = 16.2 nM 7.79
CHEMBL1164729 FEBUXOSTAT IC50 = 18.6 nM 7.73
CHEMBL3331613 IC50 = 24.8 nM 7.61
CHEMBL3331616 IC50 = 29.2 nM 7.54
CHEMBL3331619 IC50 = 30.6 nM 7.51
CHEMBL3331610 IC50 = 33.7 nM 7.47
CHEMBL3331618 IC50 = 35.4 nM 7.45
CHEMBL3331612 IC50 = 40.3 nM 7.39
CHEMBL3331624 IC50 = 45.6 nM 7.34
CHEMBL3331609 IC50 = 49.2 nM 7.31
CHEMBL3331625 IC50 = 53.8 nM 7.27
CHEMBL3331607 IC50 = 65.6 nM 7.18
CHEMBL3331608 IC50 = 82.5 nM 7.08