Assay Detail
Functional
CHEMBL3367642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.54 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018954 | — | — | 1 | 8.41 |
| CHEMBL2018953 | — | — | 1 | 8.26 |
| CHEMBL3310839 | — | — | 1 | 7.60 |
| CHEMBL3310841 | — | — | 1 | 7.30 |
| CHEMBL3310840 | — | — | 1 | 7.10 |
| CHEMBL3310833 | — | — | 1 | 6.95 |
| CHEMBL3310827 | — | — | 1 | 6.70 |
| CHEMBL3310838 | — | — | 1 | 6.70 |
| CHEMBL3310826 | — | — | 1 | 6.50 |
| CHEMBL3310837 | — | — | 1 | 6.40 |
| CHEMBL3310830 | — | — | 1 | 6.34 |
| CHEMBL3310825 | — | — | 1 | 6.22 |
| CHEMBL3310832 | — | — | 1 | 6.00 |
| CHEMBL3310836 | — | — | 1 | 5.80 |
| CHEMBL3310829 | — | — | 1 | 5.70 |
| CHEMBL3310835 | — | — | 1 | 5.70 |
| CHEMBL3310834 | — | — | 1 | 5.40 |
| CHEMBL3310828 | — | — | 1 | 4.70 |
| CHEMBL3310831 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018954 | — | IC50 | = | 3.89 | nM | 8.41 |
| CHEMBL2018953 | — | IC50 | = | 5.495 | nM | 8.26 |
| CHEMBL3310839 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3310841 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3310840 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3310833 | — | IC50 | = | 112.2 | nM | 6.95 |
| CHEMBL3310827 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL3310838 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL3310826 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3310837 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3310830 | — | IC50 | = | 457.09 | nM | 6.34 |
| CHEMBL3310825 | — | IC50 | = | 602.56 | nM | 6.22 |
| CHEMBL3310832 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3310836 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL3310829 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL3310835 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL3310834 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3310828 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL3310831 | — | IC50 | > | 31622.78 | nM | - |