Assay Detail
ADMET
CHEMBL3367715
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Inhibition of CYP2D6 in supersomes (unknown origin) using AMMC as substrate after 30 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.15 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330409 | — | — | 1 | 5.30 |
| CHEMBL3330410 | — | — | 1 | 5.00 |
| CHEMBL3330260 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330409 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3330410 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3330260 | — | IC50 | > | 10000.0 | nM | - |