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Assay Detail

CHEMBL3367775

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Functional
Antimicrobial activity against trypamastigote stage of Trypanosoma brucei after 72 hrs by Alamar Blue assay
ChEMBL ↗
49
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei (CHEMBL612849) ↗
Type ORGANISM
Organism Trypanosoma brucei

Publication

Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines.
Manda S, Khan SI, Jain SK, Mohammed S, Tekwani BL, Khan IA, Vishwakarma RA, Bharate SB.
Bioorg Med Chem Lett (2014) 24 : 3247 -3250
PubMed 24980054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.17 8.39
IC90 23 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55 PENTAMIDINE 4.0 2 8.39
CHEMBL3309544 — — 2 6.00
CHEMBL3309545 — — 2 5.05
CHEMBL3309546 — — 2 4.99
CHEMBL3309543 — — 2 4.96
CHEMBL3309536 — — 2 4.86
CHEMBL3309542 — — 2 4.80
CHEMBL440598 — — 1 4.58
CHEMBL830 EFLORNITHINE 4.0 2 4.55
CHEMBL3309541 — — 1 4.53
CHEMBL269538 HARMINE 1.0 1 4.13
CHEMBL3359596 — — 2 -
CHEMBL3309535 — — 2 -
CHEMBL3309537 — — 2 -
CHEMBL3309538 — — 2 -
CHEMBL3309539 — — 2 -
CHEMBL3309540 — — 2 -
CHEMBL267345 AMPHOTERICIN B 4.0 2 -
CHEMBL274656 — — 2 -
CHEMBL3309533 — — 2 -
CHEMBL3309266 — — 2 -
CHEMBL3309712 — — 2 -
CHEMBL3309711 — — 2 -
CHEMBL3309710 — — 2 -
CHEMBL3309709 — — 2 -
CHEMBL3309708 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55 PENTAMIDINE IC50 = 4.1 nM 8.39
CHEMBL3309544 — IC50 = 1000.0 nM 6.00
CHEMBL3309545 — IC50 = 8900.0 nM 5.05
CHEMBL3309546 — IC50 = 10200.0 nM 4.99
CHEMBL3309543 — IC50 = 11000.0 nM 4.96
CHEMBL3309536 — IC50 = 13700.0 nM 4.86
CHEMBL3309542 — IC50 = 15900.0 nM 4.80
CHEMBL440598 — IC50 = 26200.0 nM 4.58
CHEMBL830 EFLORNITHINE IC50 = 28000.0 nM 4.55
CHEMBL3309541 — IC50 = 29700.0 nM 4.53
CHEMBL269538 HARMINE IC50 = 74000.0 nM 4.13
CHEMBL3309544 — IC90 = 28100.0 nM -
CHEMBL3309709 — IC50 - — -
CHEMBL3359596 — IC50 - — -
CHEMBL3309535 — IC50 - — -
CHEMBL3309536 — IC90 = 23900.0 nM -
CHEMBL3309537 — IC50 - — -
CHEMBL3309538 — IC50 - — -
CHEMBL3309539 — IC50 - — -
CHEMBL3309540 — IC50 - — -
CHEMBL3309542 — IC90 = 26300.0 nM -
CHEMBL3309543 — IC90 = 18800.0 nM -
CHEMBL3309710 — IC50 - — -
CHEMBL3309545 — IC90 = 14500.0 nM -
CHEMBL3309546 — IC90 = 17600.0 nM -
CHEMBL55 PENTAMIDINE IC90 = 7.0 nM -
CHEMBL267345 AMPHOTERICIN B IC50 - — -
CHEMBL830 EFLORNITHINE IC90 = 68200.0 nM -
CHEMBL3309266 — IC50 - — -
CHEMBL3309708 — IC50 - — -
CHEMBL3309708 — IC90 - — -
CHEMBL3309712 — IC90 - — -
CHEMBL3309711 — IC50 - — -
CHEMBL3309711 — IC90 - — -
CHEMBL274656 — IC90 - — -
CHEMBL274656 — IC50 - — -
CHEMBL3309710 — IC90 - — -
CHEMBL3309712 — IC50 - — -
CHEMBL3309533 — IC90 - — -
CHEMBL3309709 — IC90 - — -
CHEMBL3309533 — IC50 - — -
CHEMBL3309266 — IC90 - — -
CHEMBL267345 AMPHOTERICIN B IC90 - — -
CHEMBL3309540 — IC90 - — -
CHEMBL3309539 — IC90 - — -
CHEMBL3309538 — IC90 - — -
CHEMBL3309537 — IC90 - — -
CHEMBL3309535 — IC90 - — -
CHEMBL3359596 — IC90 - — -