Assay Detail
Binding
CHEMBL3367783
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Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.81 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168815 | CEVIMELINE | 4.0 | 1 | 6.07 |
| CHEMBL387632 | — | — | 1 | 5.92 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.91 |
| CHEMBL3309718 | — | — | 1 | 5.76 |
| CHEMBL390842 | — | — | 1 | 5.68 |
| CHEMBL74300 | — | — | 1 | 5.49 |
| CHEMBL3309715 | — | — | 1 | - |
| CHEMBL3359597 | — | — | 1 | - |
| CHEMBL3309717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168815 | CEVIMELINE | Ki | = | 851.14 | nM | 6.07 |
| CHEMBL387632 | — | Ki | = | 1202.26 | nM | 5.92 |
| CHEMBL14 | CARBACHOL | Ki | = | 1230.27 | nM | 5.91 |
| CHEMBL3309718 | — | Ki | = | 1737.8 | nM | 5.76 |
| CHEMBL390842 | — | Ki | = | 2089.3 | nM | 5.68 |
| CHEMBL74300 | — | Ki | = | 3235.94 | nM | 5.49 |
| CHEMBL3309715 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3359597 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3309717 | — | Ki | > | 100000.0 | nM | - |