Assay Detail
Functional
CHEMBL3368299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human DU145 cells after 4 days by CCK-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.81 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 9.00 |
| CHEMBL3323432 | — | — | 1 | 6.44 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.02 |
| CHEMBL3321774 | — | — | 1 | 6.01 |
| CHEMBL3323427 | — | — | 1 | 5.85 |
| CHEMBL3323426 | — | — | 1 | 5.75 |
| CHEMBL3323436 | — | — | 1 | 5.71 |
| CHEMBL3323428 | — | — | 1 | 5.50 |
| CHEMBL3323431 | — | — | 1 | 5.47 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 5.41 |
| CHEMBL3323429 | — | — | 1 | 5.40 |
| CHEMBL3323425 | — | — | 1 | 5.39 |
| CHEMBL3323419 | — | — | 1 | 5.30 |
| CHEMBL3323420 | — | — | 1 | 5.27 |
| CHEMBL3323435 | — | — | 1 | 5.27 |
| CHEMBL3323437 | — | — | 1 | 5.24 |
| CHEMBL3323423 | — | — | 1 | - |
| CHEMBL3323424 | — | — | 1 | - |
| CHEMBL3323430 | — | — | 1 | - |
| CHEMBL3323433 | — | — | 1 | - |
| CHEMBL3323434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3323432 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3321774 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL3323427 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3323426 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL3323436 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL3323428 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL3323431 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL3323429 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL3323425 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL3323419 | — | IC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL3323420 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3323435 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL3323437 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3323423 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3323424 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3323430 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3323433 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3323434 | — | IC50 | > | 50000.0 | nM | - |