Assay Detail
Functional
CHEMBL3368301
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Cytotoxicity against human T47D cells after 4 days by CCK-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.32 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3323435 | — | — | 1 | 6.19 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.12 |
| CHEMBL3323432 | — | — | 1 | 6.02 |
| CHEMBL3323425 | — | — | 1 | 5.69 |
| CHEMBL3323426 | — | — | 1 | 5.65 |
| CHEMBL3323419 | — | — | 1 | 5.60 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 5.51 |
| CHEMBL3323420 | — | — | 1 | 5.47 |
| CHEMBL3323436 | — | — | 1 | 5.41 |
| CHEMBL3323427 | — | — | 1 | 5.39 |
| CHEMBL3323428 | — | — | 1 | 5.37 |
| CHEMBL3323437 | — | — | 1 | 5.35 |
| CHEMBL3323424 | — | — | 1 | 5.34 |
| CHEMBL3323431 | — | — | 1 | 5.32 |
| CHEMBL3321774 | — | — | 1 | 5.27 |
| CHEMBL3323429 | — | — | 1 | 5.24 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.06 |
| CHEMBL3323423 | — | — | 1 | 4.74 |
| CHEMBL3323430 | — | — | 1 | 4.30 |
| CHEMBL3323433 | — | — | 1 | 4.30 |
| CHEMBL3323434 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3323435 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3323432 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3323425 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL3323426 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL3323419 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL3323420 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL3323436 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL3323427 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL3323428 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL3323437 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL3323424 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL3323431 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL3321774 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL3323429 | — | IC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL3323423 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL3323430 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3323433 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3323434 | — | IC50 | = | 50000.0 | nM | 4.30 |