Assay Detail
Functional
CHEMBL3369039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human beta3 adrenergic receptor expressed in cells by cAMP accumulation assay
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of TD-4306, a long-acting β2-agonist for the treatment of asthma and COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 7.53 | 8.20 |
| pEC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298324 | — | — | 1 | 8.20 |
| CHEMBL3298987 | — | — | 1 | 8.10 |
| CHEMBL3298326 | — | — | 1 | 8.00 |
| CHEMBL3290999 | — | — | 1 | 7.90 |
| CHEMBL3298762 | — | — | 1 | 7.90 |
| CHEMBL3298692 | — | — | 1 | 7.90 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 7.60 |
| CHEMBL3298325 | — | — | 1 | 7.60 |
| CHEMBL3298832 | — | — | 1 | 7.50 |
| CHEMBL3298897 | — | — | 1 | 7.40 |
| CHEMBL1940832 | MILVETEROL | 2.0 | 1 | 7.40 |
| CHEMBL3298328 | — | — | 1 | 7.40 |
| CHEMBL3298329 | — | — | 1 | 7.40 |
| CHEMBL3298330 | — | — | 1 | 7.40 |
| CHEMBL3298691 | — | — | 1 | 7.40 |
| CHEMBL3298213 | — | — | 1 | 7.40 |
| CHEMBL3298831 | — | — | 1 | 7.30 |
| CHEMBL3298986 | — | — | 1 | 7.20 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 6.00 |
| CHEMBL3298327 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298324 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3298987 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3298326 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3290999 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3298762 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3298692 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3298325 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3298832 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3298897 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL1940832 | MILVETEROL | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3298328 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3298329 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3298330 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3298691 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3298213 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3298831 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3298986 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3298327 | — | pEC50 | - | — | - |