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Compound Detail

CHEMBL3298213

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CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1

Basic Information

ChEMBL ID CHEMBL3298213
Phase Preclinical
Structure Type MOL
InChI Key BOGKGWCOWBCLCB-SANMLTNESA-N
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

478.6
MW (Da)
3.69
ALogP
7
HBA
6
HBD
128.9
PSA (Ų)
0.13
QED
1
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H34N4O4
MW 478.59
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.28

Activity Summary

EC50 4 meas. best 9.6
Ki 1 meas. best 7.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.6 9.05 0.3 2
Beta-1 adrenergic receptor
CHEMBL213
EC50 8.2 8.2 6.3 1
Beta-2 adrenergic receptor
CHEMBL210
Ki 7.6 7.6 25.1 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 7.4 7.4 39.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24835980 10.1016/j.bmcl.2014.04.095 Beta-2 adrenergic receptor 4
24835980 10.1016/j.bmcl.2014.04.095 Unchecked 1
24835980 10.1016/j.bmcl.2014.04.095 Beta-1 adrenergic receptor 1
24835980 10.1016/j.bmcl.2014.04.095 Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine