Assay Detail
Binding
CHEMBL3369035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]dihydroalprenolol from human beta2 adrenergic receptor expressing cell membrane by competition binding assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of TD-4306, a long-acting β2-agonist for the treatment of asthma and COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.18 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298987 | — | — | 1 | 9.00 |
| CHEMBL3298326 | — | — | 1 | 8.90 |
| CHEMBL3298325 | — | — | 1 | 8.80 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 8.60 |
| CHEMBL3298324 | — | — | 1 | 8.50 |
| CHEMBL1940832 | MILVETEROL | 2.0 | 1 | 8.50 |
| CHEMBL3298329 | — | — | 1 | 8.30 |
| CHEMBL3298330 | — | — | 1 | 8.30 |
| CHEMBL3290999 | — | — | 1 | 8.20 |
| CHEMBL3298986 | — | — | 1 | 8.20 |
| CHEMBL3298691 | — | — | 1 | 8.20 |
| CHEMBL3298328 | — | — | 1 | 8.20 |
| CHEMBL3298762 | — | — | 1 | 8.00 |
| CHEMBL3298897 | — | — | 1 | 8.00 |
| CHEMBL3298327 | — | — | 1 | 7.90 |
| CHEMBL3298692 | — | — | 1 | 7.70 |
| CHEMBL3298831 | — | — | 1 | 7.70 |
| CHEMBL3298213 | — | — | 1 | 7.60 |
| CHEMBL3298832 | — | — | 1 | 7.50 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298987 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3298326 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL3298325 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL1263 | SALMETEROL | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL3298324 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1940832 | MILVETEROL | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL3298329 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL3298330 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL3290999 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL3298986 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL3298691 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL3298328 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL3298762 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3298897 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3298327 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL3298692 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL3298831 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL3298213 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3298832 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1256786 | FORMOTEROL | Ki | = | 31.62 | nM | 7.50 |