Assay Detail
Binding
CHEMBL3369379
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Displacement of [3H](Ile5,6)deltorphin-2 from DOR in rat brain membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.04 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3327220 | — | — | 1 | 8.04 |
| CHEMBL3327221 | — | — | 1 | - |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3327220 | — | IC50 | = | 9.06 | nM | 8.04 |
| CHEMBL3327221 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | > | 1000.0 | nM | - |