Assay Detail
Functional
CHEMBL3369401
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Cytotoxicity against human A2780 cells by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.62 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.40 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.22 |
| CHEMBL1809080 | — | — | 1 | 8.57 |
| CHEMBL450955 | — | — | 1 | 8.47 |
| CHEMBL551337 | — | — | 1 | 8.46 |
| CHEMBL126932 | — | — | 1 | 8.43 |
| CHEMBL126916 | — | — | 1 | 8.28 |
| CHEMBL3334709 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1809080 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL450955 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL551337 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL126932 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL126916 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3334709 | — | IC50 | = | 7.0 | nM | 8.15 |