Assay Detail
Functional
CHEMBL3370016
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new heterocyclic lupeol derivatives as nitric oxide and pro-inflammatory cytokine inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.47 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.96 |
| CHEMBL3310695 | — | — | 1 | 4.65 |
| CHEMBL3310694 | — | — | 1 | 4.62 |
| CHEMBL3310690 | — | — | 1 | 4.59 |
| CHEMBL3310689 | — | — | 1 | 4.56 |
| CHEMBL3310691 | — | — | 1 | 4.51 |
| CHEMBL3310688 | — | — | 1 | 4.50 |
| CHEMBL3310696 | — | — | 1 | 4.49 |
| CHEMBL3310693 | — | — | 1 | 4.45 |
| CHEMBL3310687 | — | — | 1 | 4.44 |
| CHEMBL453802 | LUPENYL ACETATE | — | 1 | 4.43 |
| CHEMBL289191 | LUPEOL | — | 1 | 4.43 |
| CHEMBL486393 | LUPENONE | — | 1 | 4.42 |
| CHEMBL3310426 | — | — | 1 | 4.41 |
| CHEMBL211376 | — | — | 1 | 4.41 |
| CHEMBL3310692 | — | — | 1 | 4.38 |
| CHEMBL2042333 | — | — | 1 | 4.37 |
| CHEMBL2042330 | — | — | 1 | 4.34 |
| CHEMBL3310425 | — | — | 1 | 4.31 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | IC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL3310695 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL3310694 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL3310690 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL3310689 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL3310691 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL3310688 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL3310696 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL3310693 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL3310687 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL453802 | LUPENYL ACETATE | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL289191 | LUPEOL | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL486393 | LUPENONE | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL3310426 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL211376 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL3310692 | — | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL2042333 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL2042330 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3310425 | — | IC50 | = | 48700.0 | nM | 4.31 |
| CHEMBL7890 | L-NAME | IC50 | = | 69210.0 | nM | 4.16 |