Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL2042333

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
C=C(C=O)[C@@H]1CC[C@]2(C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12

Basic Information

ChEMBL ID CHEMBL2042333
Phase Preclinical
Structure Type MOL
InChI Key RYHMCEZDZZBPAQ-QGTGJCAVSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

440.7
MW (Da)
7.20
ALogP
2
HBA
1
HBD
37.3
PSA (Ų)
0.36
QED
1
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C30H48O2
MW 440.71
Aromatic Rings 0
Heavy Atoms 32
NP-Likeness 3.15

Activity Summary

IC50 3 meas. best 5.38

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
L6
CHEMBL614793
IC50 5.38 5.38 4200.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.43 4.43 37000.0 1
RAW264.7
CHEMBL612557
IC50 4.37 4.37 42900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24813738 10.1016/j.bmcl.2014.04.059 L6 5
22462772 10.1021/np200910u Unchecked 2
24813738 10.1016/j.bmcl.2014.04.059 Insulin receptor substrate 1 2
24909081 10.1016/j.bmcl.2014.05.032 RAW264.7 2
24813738 10.1016/j.bmcl.2014.04.059 Solute carrier family 2, facilitated glucose transporter member 4 1
24813738 10.1016/j.bmcl.2014.04.059 Insulin receptor 1
24813738 10.1016/j.bmcl.2014.04.059 5'-AMP-activated protein kinase catalytic subunit alpha-1 1
24813738 10.1016/j.bmcl.2014.04.059 3T3-L1 1
24813738 10.1016/j.bmcl.2014.04.059 HepG2 1
24909081 10.1016/j.bmcl.2014.05.032 NON-PROTEIN TARGET 1
24909081 10.1016/j.bmcl.2014.05.032 ADMET 1

Data from ChEMBL 36 via Core Engine