Assay Detail
Functional
CHEMBL3370017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | J774.A1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new heterocyclic lupeol derivatives as nitric oxide and pro-inflammatory cytokine inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.47 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3310694 | — | — | 1 | 4.74 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.73 |
| CHEMBL3310690 | — | — | 1 | 4.63 |
| CHEMBL3310695 | — | — | 1 | 4.60 |
| CHEMBL3310691 | — | — | 1 | 4.54 |
| CHEMBL3310689 | — | — | 1 | 4.54 |
| CHEMBL3310688 | — | — | 1 | 4.50 |
| CHEMBL3310696 | — | — | 1 | 4.49 |
| CHEMBL453802 | LUPENYL ACETATE | — | 1 | 4.48 |
| CHEMBL3310693 | — | — | 1 | 4.48 |
| CHEMBL289191 | LUPEOL | — | 1 | 4.46 |
| CHEMBL3310687 | — | — | 1 | 4.44 |
| CHEMBL2042333 | — | — | 1 | 4.43 |
| CHEMBL3310426 | — | — | 1 | 4.41 |
| CHEMBL486393 | LUPENONE | — | 1 | 4.41 |
| CHEMBL3310692 | — | — | 1 | 4.38 |
| CHEMBL211376 | — | — | 1 | 4.37 |
| CHEMBL2042330 | — | — | 1 | 4.35 |
| CHEMBL3310425 | — | — | 1 | 4.32 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3310694 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL140 | CURCUMIN | IC50 | = | 18520.0 | nM | 4.73 |
| CHEMBL3310690 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL3310695 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL3310691 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL3310689 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL3310688 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL3310696 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL453802 | LUPENYL ACETATE | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL3310693 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL289191 | LUPEOL | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL3310687 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL2042333 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3310426 | — | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL486393 | LUPENONE | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL3310692 | — | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL211376 | — | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL2042330 | — | IC50 | = | 44600.0 | nM | 4.35 |
| CHEMBL3310425 | — | IC50 | = | 47700.0 | nM | 4.32 |
| CHEMBL7890 | L-NAME | IC50 | = | 73180.0 | nM | 4.14 |