Assay Detail
Binding
CHEMBL3370199
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Agonist activity at myc-tagged mu opioid receptor (unknown origin) expressed in AtT-20 cells assessed as induction of membrane potential hyperpolarization
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | AtT20 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.32 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3325715 | — | — | 1 | 7.00 |
| CHEMBL3325716 | — | — | 1 | 6.70 |
| CHEMBL3325714 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3325715 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3325716 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3325714 | — | EC50 | = | 5490.0 | nM | 5.26 |