Assay Detail
Binding
CHEMBL3370270
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Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins
41
Total Activities
32
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A₂, cyclooxygenases, lipoxygenase and proinflammatory cytokines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.30 | 6.68 |
| Inhibition | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.68 |
| CHEMBL3289927 | — | — | 2 | 6.43 |
| CHEMBL3289934 | — | — | 2 | 6.38 |
| CHEMBL3289926 | — | — | 2 | 6.34 |
| CHEMBL3309948 | — | — | 2 | 6.17 |
| CHEMBL3309947 | — | — | 2 | 6.14 |
| CHEMBL3289925 | — | — | 2 | 6.00 |
| CHEMBL3289933 | — | — | 2 | 5.95 |
| CHEMBL3309949 | — | — | 2 | 5.91 |
| CHEMBL3289924 | — | — | 2 | 5.75 |
| CHEMBL3289931 | — | — | 1 | 5.65 |
| CHEMBL3289930 | — | — | 1 | 5.56 |
| CHEMBL3289928 | — | — | 1 | 5.50 |
| CHEMBL3289929 | — | — | 1 | 5.49 |
| CHEMBL3289939 | — | — | 1 | 5.40 |
| CHEMBL3289932 | — | — | 1 | 5.04 |
| CHEMBL3289941 | — | — | 1 | 5.00 |
| CHEMBL3309950 | — | — | 1 | 4.84 |
| CHEMBL3289942 | — | — | 1 | 4.67 |
| CHEMBL3357954 | — | — | 1 | 4.53 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.53 |
| CHEMBL3290195 | — | — | 1 | 4.48 |
| CHEMBL3309953 | — | — | 1 | 4.47 |
| CHEMBL3290193 | — | — | 1 | 4.42 |
| CHEMBL3309954 | — | — | 1 | 4.40 |
| CHEMBL3290192 | — | — | 1 | 4.31 |
| CHEMBL3309957 | — | — | 1 | 4.29 |
| CHEMBL3309956 | — | — | 1 | 4.16 |
| CHEMBL3289940 | — | — | 1 | - |
| CHEMBL3309955 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3289927 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3289934 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3289926 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3309948 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3309947 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3289925 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3289933 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3309949 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL3289924 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL3289931 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL3289930 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL3289928 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL3289929 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL3289939 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL3289932 | — | IC50 | = | 9060.0 | nM | 5.04 |
| CHEMBL3289941 | — | IC50 | = | 9910.0 | nM | 5.00 |
| CHEMBL3309950 | — | IC50 | = | 14560.0 | nM | 4.84 |
| CHEMBL3289942 | — | IC50 | = | 21540.0 | nM | 4.67 |
| CHEMBL140 | CURCUMIN | IC50 | = | 29650.0 | nM | 4.53 |
| CHEMBL3357954 | — | IC50 | = | 29330.0 | nM | 4.53 |
| CHEMBL3290195 | — | IC50 | = | 33450.0 | nM | 4.48 |
| CHEMBL3309953 | — | IC50 | = | 33540.0 | nM | 4.47 |
| CHEMBL3290193 | — | IC50 | = | 37750.0 | nM | 4.42 |
| CHEMBL3309954 | — | IC50 | = | 39420.0 | nM | 4.40 |
| CHEMBL3290192 | — | IC50 | = | 49330.0 | nM | 4.31 |
| CHEMBL3309957 | — | IC50 | = | 51320.0 | nM | 4.29 |
| CHEMBL3309956 | — | IC50 | = | 69220.0 | nM | 4.16 |
| CHEMBL3290194 | — | IC50 | - | — | - | |
| CHEMBL3309955 | — | IC50 | - | — | - | |
| CHEMBL3290196 | — | IC50 | - | — | - | |
| CHEMBL3289940 | — | IC50 | - | — | - | |
| CHEMBL3289924 | — | Inhibition | = | 81.79 | % | - |
| CHEMBL3289925 | — | Inhibition | = | 81.79 | % | - |
| CHEMBL3289926 | — | Inhibition | = | 81.79 | % | - |
| CHEMBL3289927 | — | Inhibition | = | 81.79 | % | - |
| CHEMBL3289933 | — | Inhibition | = | 81.79 | % | - |
| CHEMBL3289934 | — | Inhibition | = | 81.79 | % | - |
| CHEMBL3309947 | — | Inhibition | = | 81.79 | % | - |
| CHEMBL3309948 | — | Inhibition | = | 81.79 | % | - |
| CHEMBL3309949 | — | Inhibition | = | 81.79 | % | - |