Assay Detail
Functional
CHEMBL3374481
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Trypanocidal activity against Trypanosoma cruzi Y epimastigotes infected in mouse J774 cells assessed as growth inhibition of parasite measured on day 5
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.82 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3319020 | — | — | 1 | 7.70 |
| CHEMBL3319018 | — | — | 1 | 7.70 |
| CHEMBL256155 | — | — | 1 | 7.30 |
| CHEMBL3319021 | — | — | 1 | 6.89 |
| CHEMBL3319019 | — | — | 1 | 6.85 |
| CHEMBL3319017 | — | — | 1 | 6.66 |
| CHEMBL3319016 | — | — | 1 | 6.28 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3319020 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3319018 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL256155 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3319021 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3319019 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3319017 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3319016 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 7000.0 | nM | 5.16 |