Assay Detail
ADMET
CHEMBL3375452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP3A4 testosterone site in human liver microsomes using midazolam as substrate by LC-MS/MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.70 | 4.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092460 | — | — | 1 | 4.84 |
| CHEMBL3092467 | — | — | 1 | 4.73 |
| CHEMBL3092468 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092460 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3092467 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL3092468 | — | IC50 | = | 28600.0 | nM | 4.54 |