Assay Detail
Binding
CHEMBL3377149
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Induction of DAT-mediated dopamine release in rat brain synaptosomes by [3H]DA release assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Alpha-ethyltryptamines as dual dopamine-serotonin releasers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.61 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471839 | — | — | 1 | 7.90 |
| CHEMBL96816 | — | — | 1 | 7.43 |
| CHEMBL1906905 | — | — | 1 | 7.26 |
| CHEMBL3330646 | — | — | 1 | 7.24 |
| CHEMBL30713 | — | — | 1 | 7.11 |
| CHEMBL275628 | — | — | 1 | 7.08 |
| CHEMBL382635 | — | — | 1 | 6.97 |
| CHEMBL381160 | — | — | 1 | 6.97 |
| CHEMBL337825 | — | — | 1 | 6.95 |
| CHEMBL3330648 | — | — | 1 | 6.82 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 6.79 |
| CHEMBL1619758 | ETRYPTAMINE | 2.0 | 1 | 6.63 |
| CHEMBL348588 | — | — | 1 | 6.49 |
| CHEMBL3330642 | — | — | 1 | 6.45 |
| CHEMBL1288717 | — | — | 1 | 6.32 |
| CHEMBL1288716 | — | — | 1 | 6.32 |
| CHEMBL3330645 | — | — | 1 | 6.18 |
| CHEMBL3330643 | — | — | 1 | 5.88 |
| CHEMBL3330644 | — | — | 1 | 5.67 |
| CHEMBL204839 | — | — | 1 | 5.47 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 4.96 |
| CHEMBL331241 | — | — | 1 | - |
| CHEMBL343529 | — | — | 1 | - |
| CHEMBL3330641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471839 | — | EC50 | = | 12.6 | nM | 7.90 |
| CHEMBL96816 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1906905 | — | EC50 | = | 54.3 | nM | 7.26 |
| CHEMBL3330646 | — | EC50 | = | 57.6 | nM | 7.24 |
| CHEMBL30713 | — | EC50 | = | 78.6 | nM | 7.11 |
| CHEMBL275628 | — | EC50 | = | 82.3 | nM | 7.08 |
| CHEMBL382635 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL381160 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL337825 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL3330648 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL6640 | TRYPTAMINE | EC50 | = | 164.0 | nM | 6.79 |
| CHEMBL1619758 | ETRYPTAMINE | EC50 | = | 232.0 | nM | 6.63 |
| CHEMBL348588 | — | EC50 | = | 321.0 | nM | 6.49 |
| CHEMBL3330642 | — | EC50 | = | 353.0 | nM | 6.45 |
| CHEMBL1288717 | — | EC50 | = | 478.0 | nM | 6.32 |
| CHEMBL1288716 | — | EC50 | = | 476.0 | nM | 6.32 |
| CHEMBL3330645 | — | EC50 | = | 654.0 | nM | 6.18 |
| CHEMBL3330643 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL3330644 | — | EC50 | = | 2118.0 | nM | 5.67 |
| CHEMBL204839 | — | EC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | EC50 | = | 11031.0 | nM | 4.96 |
| CHEMBL331241 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL343529 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3330641 | — | EC50 | > | 10000.0 | nM | - |