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Compound Detail

CHEMBL331241

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Cc1ccc2[nH]cc(CCN)c2c1

Basic Information

ChEMBL ID CHEMBL331241
Phase Preclinical
Structure Type MOL
InChI Key PYOUAIQXJALPKW-UHFFFAOYSA-N
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

174.2
MW (Da)
1.98
ALogP
1
HBA
2
HBD
41.8
PSA (Ų)
0.72
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H14N2
MW 174.25
Aromatic Rings 2
Heavy Atoms 13
NP-Likeness -0.19

Activity Summary

EC50 2 meas. best 8.22
Ki 1 meas. best 8.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 2A
CHEMBL224
EC50 8.22 8.22 6.0 1
5-hydroxytryptamine receptor 1D
CHEMBL1983
Ki 8.19 8.19 6.4 1
Sodium-dependent serotonin transporter
CHEMBL313
EC50 6.86 6.86 139.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3988442 Unchecked 3
7658443 10.1021/jm00018a016 5-hydroxytryptamine receptor 1D 2
25193229 10.1016/j.bmcl.2014.07.062 5-hydroxytryptamine receptor 2A 2
- 10.6019/CHEMBL4513160 Pseudomonas aeruginosa 2
9986723 10.1021/jm9805945 5-hydroxytryptamine receptor 1D 1
7658443 10.1021/jm00018a016 5-hydroxytryptamine receptor 2A 1
25193229 10.1016/j.bmcl.2014.07.062 Sodium-dependent dopamine transporter 1
25193229 10.1016/j.bmcl.2014.07.062 Sodium-dependent serotonin transporter 1
25193229 10.1016/j.bmcl.2014.07.062 Norepinephrine transporter 1
- 10.6019/CHEMBL4513160 Acinetobacter baumannii 1

Data from ChEMBL 36 via Core Engine