Assay Detail
Binding
CHEMBL3377150
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of 5-HTT-mediated 5-HT release in rat brain synaptosomes by [3H]5-HT release assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Alpha-ethyltryptamines as dual dopamine-serotonin releasers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 7.50 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471839 | — | — | 1 | 8.47 |
| CHEMBL381160 | — | — | 1 | 8.36 |
| CHEMBL3330643 | — | — | 1 | 8.10 |
| CHEMBL275628 | — | — | 1 | 8.00 |
| CHEMBL96816 | — | — | 1 | 7.85 |
| CHEMBL1906905 | — | — | 1 | 7.79 |
| CHEMBL3330640 | — | — | 1 | 7.73 |
| CHEMBL1288716 | — | — | 1 | 7.72 |
| CHEMBL30713 | — | — | 1 | 7.66 |
| CHEMBL348588 | — | — | 1 | 7.65 |
| CHEMBL1619758 | ETRYPTAMINE | 2.0 | 1 | 7.63 |
| CHEMBL204839 | — | — | 1 | 7.62 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 7.49 |
| CHEMBL3330647 | — | — | 1 | 7.48 |
| CHEMBL3330646 | — | — | 1 | 7.46 |
| CHEMBL3330648 | — | — | 1 | 7.44 |
| CHEMBL3330644 | — | — | 1 | 7.35 |
| CHEMBL3330642 | — | — | 1 | 7.29 |
| CHEMBL3330641 | — | — | 1 | 7.28 |
| CHEMBL337825 | — | — | 1 | 7.27 |
| CHEMBL3330645 | — | — | 1 | 7.26 |
| CHEMBL1288717 | — | — | 1 | 7.12 |
| CHEMBL382635 | — | — | 1 | 6.97 |
| CHEMBL331241 | — | — | 1 | 6.86 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471839 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL381160 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3330643 | — | EC50 | = | 8.03 | nM | 8.10 |
| CHEMBL275628 | — | EC50 | = | 10.1 | nM | 8.00 |
| CHEMBL96816 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1906905 | — | EC50 | = | 16.2 | nM | 7.79 |
| CHEMBL3330640 | — | EC50 | = | 18.6 | nM | 7.73 |
| CHEMBL1288716 | — | EC50 | = | 19.1 | nM | 7.72 |
| CHEMBL30713 | — | EC50 | = | 21.7 | nM | 7.66 |
| CHEMBL348588 | — | EC50 | = | 22.4 | nM | 7.65 |
| CHEMBL1619758 | ETRYPTAMINE | EC50 | = | 23.2 | nM | 7.63 |
| CHEMBL204839 | — | EC50 | = | 23.7 | nM | 7.62 |
| CHEMBL6640 | TRYPTAMINE | EC50 | = | 32.6 | nM | 7.49 |
| CHEMBL3330647 | — | EC50 | = | 33.2 | nM | 7.48 |
| CHEMBL3330646 | — | EC50 | = | 34.7 | nM | 7.46 |
| CHEMBL3330648 | — | EC50 | = | 36.6 | nM | 7.44 |
| CHEMBL3330644 | — | EC50 | = | 44.6 | nM | 7.35 |
| CHEMBL3330642 | — | EC50 | = | 51.6 | nM | 7.29 |
| CHEMBL3330641 | — | EC50 | = | 53.1 | nM | 7.28 |
| CHEMBL337825 | — | EC50 | = | 53.8 | nM | 7.27 |
| CHEMBL3330645 | — | EC50 | = | 54.9 | nM | 7.26 |
| CHEMBL1288717 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL382635 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL331241 | — | EC50 | = | 139.0 | nM | 6.86 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | EC50 | = | 2169.0 | nM | 5.66 |